Written by Dr.Albana Greca Sejdini, Md, MMedSc
Medically reviewed by Dr.Ruden Cakoni, MD, Endocrinologist
Hi dear readers,
I understand that fighting against diabetes remains a tough challenge for you and your medical team too. While trying to reverse some problems, perhaps, many others would appear. That’s why “patience & determination” are the mostly welcomed.
The information I wanted to share with you today is related to the recent drugs that the pharmaceutical machinery has prepared for you to fight diabetes medically (although this is not my preferred way).
In fact, this news is related to the inhibitors of the DPP-4 receptors, leading to high levels of incretin hormones.
Now, to make it more clearly to you, let me explain some things:
First, incretin hormones are those substances produced in your intestines to stimulate the pancreas for producing and secreting insulin, which is another hormone responsible to lower blood sugar levels.
The mechanisms of our body are remarkably made in such way of secreting and destroying. In fact, there is an enzyme DPP-4 (dipeptidyl peptidase-4) which inactivates the incretins at the right time when they are not needed to our body.
What the scientists have come out in our days is that they have found the way of inhibiting this DPP-4 enzyme (its receptors); thus letting the naturally produced incretins activated (around) to increase the insulin production from the pancreas.
This could help diabetics of type 2 to control their blood sugar together with lifestyle and diet changes. As you may see, no drug can really help you if you do not make the right changes in your lifestyle or/and diet. That’s why I do strongly support the natural fight against diabetes through these two strong weapons
Now, as every drug has its own side effect; the gliptins (DPP-4 inhibitors) have their own. Researchers were worried with the high risks levels attributed to the developing of cardio-vascular problems (especially to heart attack).
Therefore, they have run two trials to exclude the possibility of having heart events and presented the results at the European Society of Cardiology (ESC) 2013 Congress.
Now, you must understand that diabetes is often associated with heart diseases. At this point, cardiologists strongly support the idea of a “strict cardiovascular risk management” rather than a “strict glycemic control”.
I do not want to debate the end-points of the researchers, but, I need you to understand that you cannot control neither risk with the use of drugs only. What you eat, what you do, stress you are having will negatively affect your blood pressure and blood glucose until the moment when they won’t have any better chance than “exploding” (stroke, coma, death).
Be strong and determined to overcome every problem although you might be tired. Your body deserves to be served accordingly and accurately.
All the best!