Written by Dr.Albana Greca Sejdini, Md, MMedSc
Medically reviewed by Dr.Ruden Cakoni, MD, Endocrinologist
How does Jamuet work to lower blood sugar?
JANUMET MEDICATION FOR DIABETES
QUESTION: How does Jamuet work to lower blood sugar?
: At first, I need to remind you that the right drug name is Janumet. Actually, this drug has a very sophisticate way of acting, because of its two active substances.
The first one is known as Sitagliptine and the other one is Metformin. it is true that you can find those substances as separate drugs on the market, but when they are combined as in Janumet, they work better.
So, in purpose to understand how this drug lowers your blood glucose concentration I will explain you how every one of the substances mentioned above work. The first one - Sitagliptine inhibits an enzyme known as DPP-4 (dipeptidil peptidase -4). This enzyme is responsible for the production of hormones, which elevate your blood glucose level.
So, when this DPP-4 enzyme is inhibited, your body can’t produce those hormones and your blood glucose level is low.
Metformin, on the other hand, inhibits the production of glucose in the liver. You have to know that your body produces glucose, when your blood glucose is high.
This happens because when there is no insulin, your blood is full of glucose, but the cell can’t use it. Because of this, the cells are sending a signal to the liver and it starts to produce glucose.
Generally, this leads to greater elevation of your blood glucose level, but with the usage of Metformin, you can prevent it.
So, Janumet is real innovation in the diabetic treatment, because of the effect of the two substances it contains.
However, before start using it you just have to consult with your doctor. He/she is the only one, who is aware of your condition, which means that only your doctor can define the dose of Janumet you have to take.
At the end, I want to remind you that drugs cannot work alone. You need to follow the right lifestyle and diet to keep your diabetes under control.
All the best!
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