| Brand name | Avandia | Actos |
| Genericname | Rosiglitazone | Pioglitazone |
| Druggroup | Thiazolidinedionetype group | Thiazolidinedionetype group |
| Usedfor | Treatmentfor diabetes type 2 | Treatmentfor diabetes types 2 |
| Mechanismof action | Makesthe body more responsive to insulin. That’s how the blood sugar levelis dramatically decreased. Clinical trials have estimated that Avandiareduces the levels of glucose faster and more effective- the effectwill take place within two weeks | Thebody is more responsive to insulin, when treated with Actos. The bloodsugar level is decreased. |
| Preparations | Avandia2 mg tablets Avandia4 mg tablets Avandia8 mg tablets | Actos 15 mg tablets Actos 30 mg tablets Actos 45 mg tablets. |
| Druginteractions | Tellyou doctor, if you take any of the following drugs/foods: - Any other anti-diabetic drugs, such as: insulin,metformin, glyburide,
- Nitrates- isosorbide dinitrate
- Beta-blockers-metoprolol, propranolol
- Seizures medications: Tegretol
- Rifampin
- Liver enzyme inhibitors- increase the plasmaconcentration of the drug, which may potent the side effects.
- Liver enzyme activators- will decrease the plasmaconcentration of the drug, so the concentration will not be enough tomake sure the effect is achieved.
| Itis very important to note your doctor for drugs/foods, which you takeduring the treatment: - Anti-diabetic drugs: metformin, insulin and etc
- Nitrates-isosorbide dinitrate
- Beta-blockers
- Enzyme inhibitors increase the concentration of thedrug in the plasma and because of that people will be affected by theside effects much more often
- Enzyme activators- decrease the concentration ofthe drug and the effect will not be achieved.
|
| Sideeffects | Sideeffects, include: - Headache
- Serious cough
- heartbeat
- bone fractures
- hypoglycemia
- dizziness
- cold sweat
- fainting
- menstrual changes
- vomiting
- nausea
- hyperglycemia
- troubles breathing
| Commonside effects are: - Muscle pain
- sore throat
- menstrual cycle changes
- vision problems
- dark urine
- yellow skin
- nausea and/or vomiting
- headache
- fatigue
- dizziness
- cold chills
- rash and/or itching
- troubles breathing
|
| Howdo you store the drug | Storeat 25 C. Do not store at places, where moisture is present. Childrenare not allowed to take the drug. | Storeat 25 C, again and keep it away from moisture. Kids are not allowednear the drug. |
| Price | Avandia2 mg- 100 tablets- $127 Avandia4 mg- 100 tablets- $145 Avandia8 mg- 84 tablets- $245 | Actos15 mg- 84 tablets- $134 Actos30 mg- 84 tablets- $229 Actos45 mg- 84 tablets- $363 |
